tumors คือ: นี่คือโพสต์ที่เกี่ยวข้องกับหัวข้อนี้
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�ѹʹ��� �ʹ�ǧ�� SANSNEE SENAWONG
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Faculty of Medicine Siriraj Hospital
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��õ�Ǩ���ʹ��Դ��ҧ� ����������� �� ��Ǩ CEA, PSA, CA 15-3, Alpha-fetoprotein (AFP) ��� ���������Թ�ҡ�������õ�Ǩ���ʹ��ҧ��� �繡�õ�Ǩ�� Tumor marker (��ú觪�������)
Tumor markers (��ú觪�������) �������
����з������ͧ��ҧ����դ����Դ���� �Դ�������¹�ŧ����������� ��䡤Ǻ�������觵�������ӹǹ�ͧ���������� �������������觵������������ҧ�Ǻ�������� ����Դ�������¹�ŧ�ͧ��þѹ�ء����������� �繼�����ա�����ҧ������ਹ ������� macromolecule ���� �� ������� ���� ��繫���� �������������컡�� ���ਹ����ҹ��͡�ҡ�о���������������к���Ǣͧ�������� ����������ѧ����ö�Ŵ�������ôѧ������͡����������ʹ ������äѴ���� (biological fluid) ���� ���ա���� �����õ�ҧ� ����Դ�ҡ�������������ҹ�� ������¡����� tumor marker ���� ��ú觪������� �������ҹ������ö��Ǩ����ҡ���ʹ ���� ��äѴ���� �� ���㹪�ͧ��ͧ (ascetic fluid) ���㹪�ͧ�ʹ (pleural fluid) �ͧ��������¹��� ���¡�����Ըա�÷ҧ��ͧ��Ժѵԡ�÷���դ������٧��
�·���� ���ਹ������÷�����ҧ����������秹�� �Ҩ���͡���� 2 ������˭�� ���
1. Tumor-specific antigen (TSA): ���ਹ�СѺ����� ����������������ҹ�� ��辺����컡�� ���ѡ����÷���դس���ѵ�㹡�õͺʹͧ��С�е���к����Ԥ����ѹ��� ������Ǩ�ҷҧ��ͧ��Ժѵԡ�����ҡ�ҡ
2. Tumor-associated antigen (TAA): ���ਹ�������ǡѺ����� �Ҩ���������������� ������컡��㹺ҧ���Тͧ�Ѳ�ҡ�� ���㹤������ ���Ҩ���� ���ͧ�ҡ��ú觪������� (Tumor marker) ����ա�õ�Ǩ㹷ҧ��Թԡ㹻Ѩ�غѹ �����㹡���� tumor-associated antigen ������ �ѧ��鹻�����Ӥѭ����ͧ��Һ ���
����繤���������ǡѺ��ú觪������� (tumor marker)
�Ҩ��Ǩ���дѺ tumor marker 㹻���ҳ���� ��㹤����� ���/���� �����·���ա���ѡ�ʺ ���/���� �վ�Ҹ���Ҿ���� ������������� (benign disease) �ͧ�����з�����������ҧ tumor marker ����
��õ�Ǩ���дѺ tumor marker �٧���һ�����§���ҧ���� �������ö�͡����Ҽ�������¹������������ҧ�� ����繵�ͧ�Ԩ�ó�����仡Ѻ�š�õ�Ǩ�ҧ��Թԡ��мš�õ�Ǩ�ҧ��ͧ��Ժѵԡ������ ��õ�Ǩ��������� (follow up) ����觨��� �����֡�Ҵ�����дѺ�ͧ tumor marker �ѧ������������������ ��ҵ�Ǩ������Ǿ�����дѺ tumor marker �٧������ӴѺ ��������ͧ��������ʧ����ä������ҡ��觢�� ���ҵ�Ǩ��������дѺŴŧ ��Ҩк觪����Ҽ�������������ä�����
�дѺ tumor marker ����Ǩ�Ѵ�����Ըա�÷��ᵡ��ҧ�ѹ ���/���� ���Ըա�����ǡѹ����ش����ҵ�Ǩ (diagnostic test kit) ��ҧ�ѹ �Ҩ����ҷ���դ���ᵡ��ҧ�ѹ�� �ѧ��� ��õԴ����š�÷��ͺ (follow up) ��þԨ�óҨҡ�š�õ�Ǩ�ͧ��ͧ��Ժѵԡ�����ǡѹ�ء����
����ª��ͧ��ú觪������� (tumor marker) 㹷ҧ��Թԡ
1. �����ԹԨ����ä����� �µ�ͧ�Ԩ�ó�����仡Ѻ����ѵ�, ��õ�Ǩ��ҧ���, ��õ�Ǩ�ҧ��ͧ��Ժѵԡ�� ��С�õ�Ǩ�ҧ���ᾷ������ �� X-ray, ultrasound �繵�
��õ�Ǩ���дѺ tumor maker �٧���һ�����§���ҧ���� �ѧ�������ö������ԹԨ���������ä������� ���ҡ��Ǩ�Դ����дѺ�ͧ tumor marker ������� ���� ��о�����дѺ tumor marker �դ���٧������ӴѺ �ʴ���ҹ��ʧ�����Ҩ����ä�����
��֧����Ǩ tumor marker ���Ǿ�����дѺ�����ࡳ�컡�� ���������ѹ����Һؤ�ż���������������� ���ͧ�ҡ�дѺ tumor marker �ѡ������ѹ��Ѻ��Ҵ�������Тͧ�ä����� �ѧ��鹼��������������������á �֧�ѧ�Ҩ���дѺ tumor marker ������
2. ���µ�Ǩ��ͧ (screening) �ä����秺ҧ��Դ㹤�����դ�������§�٧ 㹻Ѩ�غѹ�� tumor marker ��§ 2 ��Դ��ҹ�� ������Ѻ�������Ѻ�������ö���Ǩ��ͧ�ä�����㹤�����դ�������§����ä����秺ҧ��Դ�٧�� ���� Alpha-fetoprotein (AFP) 㹤�����繵Ѻ�ѡ�ʺ������ѧ (chronic hepatitis), hepatitis B carrier, �Ѻ�� (cirrhosis) ���͵�Ǩ��ͧ��������秵Ѻ ��� Prostate specific antigen (PSA) 㹼���·�������� 50 �բ��� �������·���ջѭ�һ�������Ӻҡ ���͵�Ǩ��ͧ��������秵����١��ҡ
3. ��Դ����š���ѡ����С�á�Ѻ�繫�Ӣͧ�ä����� �繻���ª����������ҡ����ش�ͧ tumor marker �����������㹻Ѩ�غѹ �¼���������秷���Ǩ��������дѺ tumor marker �٧�����������á�ԹԨ��� ��ѧ�ҡ���Ѻ����ѡ������ �дѺ tumor marker ������٧������� ��ä���� Ŵŧ�Ҩ��֧�дѺ���� �����дѺ tumor marker �����Ŵŧ��ѧ����ѡ�� ��Ѻ�դ���٧������ӴѺ���ҧ������ͧ�ա���� �ʴ���ҹ�Ҩ��ա�á�Ѻ������ͧ�ä����� �¡������¹�ŧ�ͧ�дѺ tumor marker ������٧�����ѧ����ѡ�� �ѡ��Ǩ��������е�Ǩ���ҡ���ʴ��ҧ��Թԡ ����»���ҳ 2-6 ��
4. ��ҡó��ä ���ͧ�ҡ�дѺ tumor marker ���üѹ������Тͧ�ä����� �ѧ��鹶�ҵ�Ǩ���дѺ tumor marker �٧�ҡ �ʴ��������秹�Ҩ��բ�Ҵ�˭� �����ա������Ш������
5. �Ҩ��������㹡�����͡�Ըա���ѡ���ä����� �� ��õ�Ǩ�� estrogen receptor ��� progesterone receptor �ͧ�������������ҹ� �������͡����������ѡ�Ҵ����ҵ�ҹ������� �繵�
��ú觪������� (tumor marker) ����Ǩ�ѹ����� ����
Alpha-fetoprotein (AFP)
Carcinoembryonic antigen (CEA)
Prostate specific antigen (PSA)
CA 125
CA 19-9
CA 15-3
Beta-human chorionic gonadotropin (beta-HCG)
Neuron-specific enolase (NSE)
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��õ�Ǩ����ú觪������� ���� tumor marker �ҡ���ʹ �繡�õ�Ǩ����÷���Ե�ҡ��������� ����Ҩ�դ������������٧�ҡ�ѡ ������ö����ᾷ����㹡�õ�Ǩ������秺ҧ�ó� �ҡ���ա������¹�ŧ�дѺ������ͧ㹼����¡��������§ �����Ҩ����µԴ�������ѡ�� ���ͺ͡��þ�ҡó��ä�� ��ҹ����ö�֡����������´�ͧ tumor marker ��Դ��ҧ� ��ҡ������
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20/10/2553 10:41:18
[Update] RECIST | tumors คือ – Sonduongpaper
RECIST (Response Evaluation Criteria in Solid Tumours) provides a simple and pragmatic methodology to evaluate the activity and efficacy of new cancer therapeutics in solid tumors, using validated and consistent criteria to assess changes in tumor burden. The RECIST Working Group comprises representatives of the European Organization for Research and Treatment of Cancer (EORTC), National Cancer Institute (NCI) of the United States and Canadian Cancer Trials Group (CCTG), as well as several pharmaceutical companies. Its mission is to ensures that RECIST undergoes continued testing, validation and updating.
Breast Biopsy Wire Guided Surgery – PreOp Patient Education \u0026 Patient Engagement
Breast Biopsy Wire Guided Surgery PreOp Patient Education \u0026 Patient Engagement
https://store.preop.com/shop/oncologycenter/breastbiopsywireguide/
Before we talk about treatment, let’s start with a discussion about the human body and about your medical condition.
Your doctor has recommended that you undergo a breast biopsy procedure or lumpectomy. But what does that actually mean?
Biopsy is a general term which simply means \”the removal of tissue for microscopic examination.\”
Your doctor intends to remove tissue from the breast not because you’re necessarily ill but because breast biopsy is a very accurate method for analyzing breast tissue.
Medical Malpractice
Because it provides such accurate diagnostic information, breast biopsy is an important diagnostic tool in the fight against breast cancer.
In your case, you have lump in your breast which is too small to be felt by touch.
Your radiologist detected this abnormality while reviewing your recent mammogram or breast xray. Let’s take a moment to look at the reasons why lumps form in breast tissue.
Medical Malpractice
The breast is made of layers of skin, fat and breast tissue all of which overlay the pectoralis muscle. Breast tissue itself is made up of a network of tiny milkcarrying ducts and there are three ways in which a lump can form among them.
Most women experience periodic changes to their breasts. Cysts are some of the most common kinds of tissues that can grow large enough to be felt and to cause tenderness. Cysts often grow and then shrink without any medical intervention.
A second kind of lump is caused by changes in breast tissue triggered by the growth of a cyst. Even after the cyst itself has gone away, it can leave fibrous tissue behind. This scar tissue can often be large enough to be felt.
The third kind of growth is a tumor. Tumors can be either benign or cancerous and it is concern about this type of growth that has lead your doctor to recommend breast biopsy.
Sometimes you will have breast changes that can not be felt by physical examination alone; but may be seen on a mammogram.
In this video we will focus only on simple needle biopsy which is the attempt to use a hollow needle to take a sample of the tissue in question.
In order to learn more about the nature of the lump in your breast your doctor would like to surgically remove it.
If you’re feeling anxious, try to remember that the purpose of a biopsy is simply to find out what is going on in your body so that if you do have a problem, it can be diagnosed and treated as quickly as possible.
If you should decide not to allow your doctor to perform the biopsy, you’ll be leaving yourself at risk for medical problems.
If the suspicious tissue in your breast is benign, most likely you’ll suffer few if any complications. However, if it is cancerous, and it is allowed to grow unchecked you might be putting your own life at risk.
The bottom line trust that your doctor is recommending this procedure for your benefit and above all don’t be afraid to ask questions raised by this video and to talk openly about your concerns.
Your Procedure: A Patient Education \u0026 Patient Engagement Company
On the day of your operation, you will be asked to put on a surgical gown.
You may receive a sedative by mouth and an intravenous line may be put in.
You will then be transferred to the operating table.
Your doctor will scrub thoroughly and will apply an antiseptic solution to the skin around the area where the needle will be inserted.
Then, the doctor will place a sterile drape or towels around the operative site and will inject a local anesthetic. This will sting a bit, but your breast will quickly begin to feel numb. Usually, the surgeon will inject more than one spot in order to make sure that the entire area is thoroughly numb
After allowing a few minutes for the anesthetic to take effect, the surgeon will insert the biopsy needle and guide it toward the lump.
You will feel some pressure or even slight tugging or pulling but you should not feel any sharp pain. If you do begin to feel pain, you should tell the doctor.
Once the tip of the needle has penetrated the lump, the doctor will draw material from the lump up into the collection chamber.
Depending on the size and location of the lump your doctor may choose to reposition the needle and draw additional tissue for analysis.
Finally, a sterile dressing is applied.
Your specimen will be sent immediately to a lab for microscopic analysis. Your doctor will tell you when to expect result from those tests.
A Patient Education \u0026 Patient Engagement Company
©2018 medselfed, Inc.
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Benign Tumor Vs Malignant Tumor ( Clear Comparison )
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Key words :
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EP.3 Clinical approach to meningioma – WEBINAR Tumors The Series
มาอัพเดทความรู้ไปกับ WEBINAR Tumors The Series;
From conventional to alternative treatments
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EP.3 Clinical approach to meningioma
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ผศ.น.สพ.ดร.นิรุตติ์ สุวรรณา
Renal Cell Carcinoma for USMLE
Renal Cell Carcinoma Anatomy, Epidemiology, Etiology, Clinical Signs and Symptoms, Treatment and Management. Handwritten, full lecture for medical students taking USMLE.
Renal Cell Carcinomas make up 9095% of kidney neoplasms.
ETIOLOGY of Renal Cell Carcinoma
Smoking is the largest risk factor. Obesity and Hyppertension is a known risk factor for Renal Cell Carcinoma in Women. Occupational Exposure such as Trichloroethylene, Benzine, Herbicides, Vinyl Chloride. Drugs associated with Renal Cell Carcinoma (phenacitin). Long term dialysis increases the risk of cystic Diseases which increase risk of renal cell carcinoma.
Von Hipel Lindau Loss of 3p increases HIF which increases angiogenesis. Also increase risk of pheochromocytoma, pancreatic cysts/islet cell tumors, retinal angiomas, CNS hemangioblastomas.
Hereditary Papillary Renal Carcinoma MET Gene mutation of tyrosine kinase domain and will have bilateral multifocal papillary renal cell carcinoma.
BurtHoggDube Syndrome Bilateral Multifocal oncocytoma which has a better prognosis. Also may cause pulmonary and colonic tumors.
CLINICAL SIGNS AND SYMPTOMS of Renal Cell Carcinoma.
The three most common presenting signs and symptoms is flank pain, hematuria, flank mass. A large percentage of patients may be asymptomatic. Patients with renal cell carcinoma may also have wieght loss, varicocele, malaise, fever.
Paraneoplastic syndromes are very common in renal cell carcinoma. Increase EPO may lead to polycythemia, Renin production may lead to hypetension. Finally may also have hypercalcemia, polyneuropathy.
Shauffer Syndrome Nonmetastatic Hepatic Dysfunction and therefore it is important to monitor liver function, even if no metastasis has occurred.
Metastasis to Lungs (45%), Soft tissue and Liver.
Work Up for Renal Cell carcinoma
Labs Urinalysis, CBC, Electrolytes, Renal Profile, LFT (AST/ALT) and Serum Calcium.
Imaging CT scan is the imaging of choice and can identify the tumor and rule out cystic mass. Also allows visualtion of Lymph nodes, Renal Vein, IVC and helps rule out angiolipoma.
For staging abdominal ;pelvic CT with or without contrast. Chest Xray and Brain MRI.
Histology
Clear Cell Carcinoma 75%, lipid/glycogen
Chromphilic Bilateral mulftifocal
Chromophobic Large polygonal Cells
Oncocytoma Rarely metastasize
Collecting Tubules
STAGING OF Renal Cell Carcinoma
Stage 1 Within the kidney and less than 7cm.
Stage 2 Within the kidney and greater than 7cm.
Stage 3 Invasion Renal Vein and Inferior Vena Cava or Adrenal Gland, but does not invade Gerota’s Fascia
Stage 4 Extends below Gerota’s Fascia, invade nearby lymph nodes and metastasis to organs.
MANAGEMENT of Renal Cell Carcinoma
Surgical
Partial nephrectomy for stage 1 and sometimes stage 2
Radical Nephrectomy remove complete removal of Gerota’s fascia, Removal of kidney with adrenal gland, dissect enlarge lymph nodes.
Palliative Nephrectomy remove kidney to alleviate pain, polycythemia and hypertension.
Adjuvant Treatment for Renal Cell Carcinoma
Biologic Response Mediators IL2 (activates T Cell and NK), IFN
Molecular Targeting Suritinib, Bevacizumab, Dazopomib, Temsirolimu, Sorafenib.
Chemotherapy 5 floururacil, Vinblastine, Paclitaxel, Caboplatin, Ifosfamide, Gemcitabine.
Radiation Renal Cell Carcinoma is not sensitive to radiation but the brain metastasize are sensitive.
Renal Artery Embolization inject ethanol or gelatin sponge pledgets in artery feeding tumor to help kill off the tumor. Also done palliative for nonsurgical patient.
Cancer Immunotherapy
Visit our website to learn more about using Nucleus content for patient engagement and content marketing: http://www.nucleushealth.com/
CancerImmunotherapy Immunotherapy CancerTreatment
MEDICAL ANIMATION TRANSCRIPT:
This video will show you what cancer immunotherapy is and how it works. Immunooncology is the study and development of certain treatments called immunotherapies for cancer. These treatments fight cancer by strengthening your immune system. Normally, the white blood cells of your immune system help fight infections and disease. They recognize substances on the surface of cells called antigens. Healthy cells have different antigens than damaged body cells or foreign invaders. Your immune cells usually ignore the antigens on healthy cells, but they do respond to antigens on damaged cells and foreign invaders. Some immune cells mark these antigens for destruction with a substance called an antibody. Then, other immune cells attack the cells that have these antibodies. Since cancer is made up of damaged cells, they may have antigens that your immune cells recognize and attack. But, some cancer cells have ways to avoid destruction by your immune cells. For example, cancer cells may reduce the number of cancer antigens, allowing them to hide from your immune cells. A second way cancer cells avoid destruction is through checkpoint proteins. Both cancer and immune cells may have these proteins. When they attach, other immune cells won’t attack the cancer cell. A third way cancer cells avoid destruction happens when the cancer cells are under attack from the immune system. During the attack, the cancer cells release certain substances that call in other types of immune cells, which slow down or stop the immune response. Immunotherapies have several ways they work to help your immune system fight cancer. One way is through special antibodies made in the lab. Some of these antibodies attach to cancer cells. They can kill the cancer cell directly. Others mark the cancer cells so that your immune cells destroy it. Another group of antibodies blocks the checkpoint proteins. This keeps them from attaching to each other. As a result, the immune cell can attack and kill the cancer cell. Still other antibodies prevent the growth of cancer cells. Some of them block the signals that cause new blood vessels to grow and feed the cancer. In another type of immunotherapy, some of the immune cells that best fight cancer are removed from the body. The cells are taken to a lab where many more of them are grown. Then, they’re returned to the body to attack the cancer. To find out more about the ways immunooncology can help fight cancer, talk to your healthcare provider.
ANH18211
นอกจากการดูบทความนี้แล้ว คุณยังสามารถดูข้อมูลที่เป็นประโยชน์อื่นๆ อีกมากมายที่เราให้ไว้ที่นี่: ดูวิธีอื่นๆWiki
ขอบคุณมากสำหรับการดูหัวข้อโพสต์ tumors คือ